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How Does Mounjaro Work for Weight Loss

  • Dec 29, 2023

Mounjaro, also known as tirzepatide, demonstrated its effectiveness in promoting weight loss through clinical studies. Long-term usage demonstrated consistent results in sustained weight reduction, exceeding 20% after 72 weeks, outperforming a placebo. Mounjaro offers promising prospects for lasting weight management.

Is Mounjaro (tirzepatide) approved for weight loss?

Yes, the active ingredient tirzepatide found in Mounjaro is approved for weight loss under the brand name Zepbound. Zepbound and Mounjaro share the same active ingredient and are manufactured by the same company.

It’s important to note that the Mounjaro brand itself is not approved for weight loss by the FDA. Mounjaro is an FDA-approved medication designed to improve blood sugar (glucose) levels in adults with type 2 diabetes mellitus when used in conjunction with diet and exercise.

How does Mounjaro contribute to weight loss?

Mounjaro facilitates weight loss through a multi-faceted approach:

Reduced Food Intake:

Mounjaro diminishes food intake by slowing down the digestive process, particularly gastric emptying. This effect contributes to an extended feeling of fullness, leading to a decrease in overall food consumption. Studies suggest that this action may be centered in the brain.

Activation of Receptors:

As a singular molecule, Mounjaro activates glucose-dependent insulinotropic polypeptide (GIP) receptors and glucagon-like peptide-1 (GLP-1) receptors. Both GIP and GLP-1 are natural incretin hormones.

GIP has demonstrated the ability to reduce food intake and increase energy expenditure, fostering weight loss. When paired with a GLP-1 receptor agonist, this combination may result in more pronounced positive effects on both blood glucose levels and body weight.

Slowed Digestive Movement:

Mounjaro retards the movement of food from the stomach into the small intestine. This deliberate deceleration contributes to an enhanced sense of fullness, prompting individuals to eat less.

Improved Insulin Response:

Weight loss facilitated by Mounjaro can positively impact insulin response. Improved responsiveness to insulin released by the pancreas can help lower blood sugar levels.
In summary, Mounjaro’s weight loss benefits are realized through a combination of reduced food intake, activation of specific receptors, slowed digestive processes, and improved insulin response, collectively working to support overall metabolic well-being.

Importance of consulting an expert before taking Mounjaro injections

Before prescribing Mounjaro for weight loss, your bariatric surgeon will conduct a thorough assessment of your body, health history, and current physical condition. It is imperative for patients to consult with an expert before undergoing any injections aimed at weight loss. This consultation serves to minimize potential side effects and complications.

It is crucial that you consult with your doctor to determine the safety and suitability of using Mounjaro for weight loss. The expertise of a bariatric surgeon ensures a personalized evaluation, considering individual health considerations and optimizing the potential benefits of the treatment.


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